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RESEARCH PROGRAMMES

P3: Nanomedicine against cancer and infection

P6: Technology translational platform

RESEARCH SUPERVISOR(S)

Prof. Isabel Rodríguez
Research Group website: https://nanociencia.imdea.org/nanostructured-functional-surfaces-program/group-home

Dr. Jorge Trasobares
Research Group website: https://www.nanociencia.imdea.org/home-en/people/item/trasobares

RESEARCH TOPIC DESCRIPTION

Recent studies have demonstrated the existence of the so-called Gut-Brain Axis (GBA) as a bi-directional communication system between the central nervous system and the gut microbiota. The GBA has been recognized as playing an important role in the development and progression of certain neurological conditions and neurodegenerative diseases. However, the mechanisms underlying the GBA bidirectional communication are still largely unknown.

Hence, this project is intended to study the GBA to improve our understanding of the nature of its bidirectional communication. For this, a GBA on a chip model will be created to host the corresponding neuron and bacteria cultures. The bioelectrical signals arising from bacteria will be monitored by in situ integrated electrochemical sensory elements.

This project will be implemented as collaboration between IMDEA Nanociencia and the Faculty of Biology at the Complutense University of Madrid in collaboration with Dra. Celia Herrera Rincon who is an expert on GBA and complex biological systems, and with Dr. Jorge Trasobares that has large experience in the electrochemical sensing.

POSITION DESCRIPTION

A typical background would include experience and knowledge on microfluidics and biophysics. Previous experience in constructing organ on a chip devices and cell culture on a chip will be very valuable. We expect the successful candidate to be highly motivated in advancing science through a multidisciplinary approach. Proficiency in English is required.

PARTNER ORGANIZATIONS

This project will be carried out in close collaboration with Dra. Celia Herrera Rincon and Dr. Jorge Trasobares from the Biology Faculty of the Universidad Complutense de Madrid, where a secondment is planned.

Other option for secondment depending on the evolution of the project will be:

Prof Stefano Geuna, Department of Clinical and Biological Sciences, University of Turin. https://en.unito.it/persone/stefano.geuna

    Image: Mouse cortical neurons