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Research Lines

METALCOMIC

  • Correlative microscopy to identify intracellular targets of antitumor metalloids.

 

Relevant publications

  1. Mathelié-Guinlet*, F. Viela*, G. Pietrocola, P. Speziale, D. Alsteens, Y.F. Dufrêne. Force clamp spectroscopy identifies a catch bond in Gram-positive pathogens. Nature communications, 2020, 11, 5431.
  1. Mathelié-Guinlet, F. Viela, M. J. Alfeo, G. Pietrocola, P. Speziale, and Y. F. Dufrêne. Single-molecule analysis demonstrates stress-enhanced binding between Staphylococcus aureus surface protein IsdB and host cell integrins. Nano letters, 2020, 20, 12, 919-8925.
  2. F. Viela, M. Mathelié-Guinlet, G. Pietrocola, P. Speziale, Y.F. Dufrêne. The molecular complex between staphylococcal adhesin SpsD and fibronectin sustains mechanical forces in the nanonewton range. mBio. 2020. 11:e00371-20

Dr. Felipe Vela obtained his Bachelor’s Degree in Biochemistry by Universidad de Zaragoza in 2012. In 2013, he received his Master’s degree in Molecular and Cellular Biology by the Universidad de Zaragoza and his PhD Degree in Biophysics “summa cum laude” by Universidad Autónoma de Madrid in 2017.

During his PhD, he worked on the fabrication of bioinspired polymer nanotopographies to control bacteria and stem cell response. He used nanoimprint lithography to fabricate these polymer surfaces and  characterized their influence in cell biological functions. He found that these nanotopographies can induce bacterial death and influence stem cell functions such as proliferation, morphology or migration. 

In 2017, he moved as a postdoctoral researcher to the laboratory of Prof. Yves Dufrêne at the Université Catholique de Louvain (Belgium), who is a world leader in the application of force nanoscopy techniques to cellular interactions. There, he performed single cell and single molecule force spectroscopy experiments with atomic force microscopy to better understand celular adhesion. During his postdoctoral stay, he authored 16 papers (6 of them as first author). 

More information on the IDEAL Fellowships Programme https://idealcofund-project.eu/postdoc/

The IDEAL Fellowships Programme is supported by the Marie Skłodowska-Curie Actions (MSCA) COFUND. Grant agreement ID: 101034431.