{"id":868,"date":"2021-06-30T16:54:14","date_gmt":"2021-06-30T14:54:14","guid":{"rendered":"https:\/\/idealcofund-project.eu\/?page_id=868"},"modified":"2021-07-02T10:30:01","modified_gmt":"2021-07-02T08:30:01","slug":"intracellular-temperature-measurements-for-disease-theranostics","status":"publish","type":"page","link":"https:\/\/idealcofund-project.eu\/postdoc\/research-topics\/intracellular-temperature-measurements-for-disease-theranostics\/","title":{"rendered":"Intracellular temperature measurements for disease theranostics"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; background_enable_image=&#8221;off&#8221; custom_padding=&#8221;2px||12px|||&#8221; global_module=&#8221;509&#8243;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; custom_padding=&#8221;4px|||||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_divider divider_weight=&#8221;60px&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][lwp_divi_breadcrumbs home_text=&#8221;Inicio&#8221; use_before_icon=&#8221;off&#8221; link_color=&#8221;#89B7CA&#8221; current_text_color=&#8221;#001733&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||0px|||&#8221;][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_text disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.4&#8243; _dynamic_attributes=&#8221;content&#8221; _module_preset=&#8221;default&#8221; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#89B7CA&#8221; text_font_size=&#8221;42px&#8221; text_line_height=&#8221;1.8em&#8221; header_line_height=&#8221;1.5em&#8221; custom_margin=&#8221;-8px|||||&#8221;]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221;][et_pb_row _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.3&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||29px|||&#8221;]<\/p>\n<h2><strong>RESEARCH PROGRAMMES <\/strong><\/h2>\n<p>P3: Nanomedicine against cancer and infection<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<h2><strong>RESEARCH SUPERVISOR(S)<\/strong><\/h2>\n<p>Dr Sebastian A. Thompson<br \/>Research Group website: <span><a href=\"https:\/\/thompson-lab.net\">https:\/\/thompson-lab.net<\/a><\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;27px||29px|||&#8221;]<\/p>\n<h2><strong>RESEARCH TOPIC DESCRIPTION<\/strong><\/h2>\n<p>Our laboratory located at IMDEA Nanociencia is focused on intracellular temperature measurements. We strongly believe that intracellular temperature can be used as source of important information for both disease diagnostic and treatment (theragnostic). The lab research lines involve the development of optics nanothermometers and their applications in cell culture, animals and, in the future, clinical applications. Currently, the main research area is the cancer discrimination based on intracellular temperature measurements. Together with this, the development of nanoparticles capable of measure intracellular temperature and generate heat simultaneously is performed to induce selective cancer cell death. Our lab and research lines combine Optics, Nanotechnology and Molecular Biology, each of the play a fundamental role.<\/p>\n<p>The applicant is expected to write an interdisciplinary research proposal in the field of intracellular temperature measurements to diagnose or\/and to treat cancer or inflammatory conditions to metabolic disorders. We can work with simulation (simulate the performance of nanothermometers), we can do nanotechnology experiments (design new nanothermometers), cell culture experiments (to unravel diseases mechanism based on intracellular temperature) and animal experiments (treat diseases based on intracellular temperature).<\/p>\n<p>The latest publications from our lab are:<\/p>\n<ul>\n<li>An anisotropy-based fluorescent tracker of cellular activity. <span style=\"font-size: 16px;\">Rodriguez G Spicer, CM Garcia-Abad, E Alejo, S Thompson. Subbmitted to Nature Photonics.<\/span><\/li>\n<li>Tryptophan-containing proteins as label-free nanothermometers. G Spicer, CM Garcia-Abad, E Alejo, S Thompson. arXiv: 2021.<\/li>\n<li>Harnessing DNA for Nanothermometry. G Spicer, S Gutierrez\u2010Erlandsson, R Matesanz, H Bernard, A Adam and S. Thompson Journal of Biophotonics 12020.<\/li>\n<li>Universal guidelines for the conversion of proteins and dyes into functional nanothermometers. G Spicer, A Efeyan, AP Adam, SA Thompson Journal of biophotonics 12 (9).<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||29px|||&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2><strong>POSITION DESCRIPTION<\/strong><\/h2>\n<p>The applicant is expected to understand that science is nowadays interdisciplinary, the laboratory combines Optics, Nanotechnology and Molecular Biology. A typical background would be interdisciplinary (or willing to work in an interdisciplinary project) with knowledge in more that one of the aforementioned fields<em> (Physics: Optics, theory, and simulations; Molecular Biology: Cancer research, inflammatory conditions to metabolic disorders; Chemistry: Nanotechnology, Analytic, Organic and Biochemistry). <\/em><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<h2><strong>PARTNER ORGANIZATIONS<\/strong><\/h2>\n<p>Based on the research proposal, we will collaborate with:<\/p>\n<ul>\n<li>Molecular Biology: Dr Alejo Efeyan: <a href=\"https:\/\/aefeyan.wixsite.com\/efeyanlab\">Metabolism and Cell Signaling Laboratory<\/a>. Group leader \u2013 CNIO (Madrid Spain).<\/li>\n<li>Inflammatory conditions to metabolic disorders:\u00a0 Dr Alejandro Adam.<a href=\"https:\/\/www.adamlabs.org\/home\"> Albany Medical College <\/a>Group leader. Albany, NY (USA).<\/li>\n<li>Physics: <a href=\"https:\/\/sites.google.com\/site\/fluorescenceimaginggroup\/\">NanoBig<\/a>. Autonomous University of Madrid (Madrid).<\/li>\n<li>Dr Jana Nieder <a href=\"https:\/\/inl.int\/inl-people\/jana-nieder\/\">International Iberian Nanotechnology Laboratory<\/a> (Braga, Portugal).<\/li>\n<li>Nanotechnology:\u00a0 Dr. Roberto de la Rica \u2013 <a href=\"http:\/\/www.delaricalab.com\/contact\/\">Bionano. Balearic Islands Health Research Institute\u00a0<\/a><\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_image src=&#8221;https:\/\/idealcofund-project.eu\/postdoc\/wp-content\/uploads\/2021\/06\/INTRACELLULARTEMPERATURE-1.jpg&#8221; title_text=&#8221;INTRACELLULARTEMPERATURE-1&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p>Nanoparticles capable of diagnose and treat cancer.<\/p>\n<p>[\/et_pb_text][et_pb_divider show_divider=&#8221;off&#8221; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||22px|||&#8221;][\/et_pb_divider][et_pb_image src=&#8221;https:\/\/idealcofund-project.eu\/postdoc\/wp-content\/uploads\/2021\/06\/INTRACELLULARTEMPERATURE-2.jpg&#8221; title_text=&#8221;INTRACELLULARTEMPERATURE-2&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p>Intracellular temperature measurements.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_image src=&#8221;https:\/\/idealcofund-project.eu\/postdoc\/wp-content\/uploads\/2021\/06\/INTRACELLULARTEMPERATURE-3.jpg&#8221; title_text=&#8221;INTRACELLULARTEMPERATURE-3&#8243; _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.9.4&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p>DNA as nanothermometer<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module lwp_divi_breadcrumbs lwp_divi_breadcrumbs_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"lwp-breadcrumbs\"> <span class=\"before\"><\/span> <span vocab=\"https:\/\/schema.org\/\" typeof=\"BreadcrumbList\"><span property=\"itemListElement\" typeof=\"ListItem\"><a property=\"item\" typeof=\"WebPage\" href=\"https:\/\/idealcofund-project.eu\/postdoc\/\" class=\"home\"><span property=\"name\">Inicio<\/span><\/a><meta property=\"position\" content=\"1\"><\/span> <span class=\"separator et-pb-icon\">&amp;#x39;<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>RESEARCH PROGRAMMES P3: Nanomedicine against cancer and infectionRESEARCH SUPERVISOR(S) Dr Sebastian A. ThompsonResearch Group website: https:\/\/thompson-lab.netRESEARCH TOPIC DESCRIPTION Our laboratory located at IMDEA Nanociencia is focused on intracellular temperature measurements. We strongly believe that intracellular temperature can be used as source of important information for both disease diagnostic [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":625,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-868","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Intracellular temperature measurements for disease theranostics - IDEAL Postdoctoral Cofund<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intracellular temperature measurements for disease theranostics - IDEAL Postdoctoral Cofund\" \/>\n<meta property=\"og:description\" content=\"RESEARCH PROGRAMMES P3: Nanomedicine against cancer and infectionRESEARCH SUPERVISOR(S) Dr Sebastian A. 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