{"id":1593,"date":"2023-03-29T09:46:39","date_gmt":"2023-03-29T07:46:39","guid":{"rendered":"https:\/\/idealcofund-project.eu\/postdoc\/?page_id=1593"},"modified":"2023-03-29T09:57:39","modified_gmt":"2023-03-29T07:57:39","slug":"intracellular-journey-of-transition-metal-catalysts","status":"publish","type":"page","link":"https:\/\/idealcofund-project.eu\/postdoc\/research-topics\/intracellular-journey-of-transition-metal-catalysts\/","title":{"rendered":"Intracellular journey of transition metal catalysts"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.9.4″ _module_preset=”default” background_enable_image=”off” custom_padding=”2px||12px|||” global_module=”509″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” custom_padding=”4px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider divider_weight=”60px” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][lwp_divi_breadcrumbs home_text=”Inicio” use_before_icon=”off” link_color=”#89B7CA” current_text_color=”#001733″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” custom_margin=”||29px|||” global_colors_info=”{}”]<\/p>\n

RESEARCH PROGRAMMES <\/strong><\/h2>\n

P3: Nanomedicine against cancer and infection<\/p>\n

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RESEARCH SUPERVISOR(S)<\/strong><\/h2>\n

Dr. Ana M. Pizarro
Research Group website: https:\/\/nanociencia.imdea.org\/metallodrugs-to-modulate-cancer-cell-machinery\/group-home<\/a><\/p>\n

Dr. Jos\u00e9 Javier Conesa
Research Group website: http:\/\/www.cnb.csic.es\/index.php\/es\/component\/k2\/item\/1668-correlative-microscopy<\/a>\u00a0<\/p>\n

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RESEARCH TOPIC DESCRIPTION<\/strong><\/h2>\n

Cancer is one of the leading causes of death. Despite efforts invested into targeted- and immuno-therapies, current estimates indicate that by 2030 cancer will cause 13M deaths worldwide.<\/p>\n

An emerging field promises to provide new ways to modulate the complex chemistry of the cancer cell is intracellular artificial catalysis<\/em>. Small molecules based on transition metals can facilitate \u2013and amplify\u2013 specific chemical reactions inside the cell.<\/p>\n

There is a tremendous gap between knowing the chemical behaviour of the metal-based drug candidate and how it relates to cytotoxicity. For most metallodrugs, we do not even know where they are located inside the cell. This gap is undoubtedly the major challenge in their pre-clinical development as studies of organometallic catalytic reactions in living cells are inherently location-specific. Unambiguous understanding of the path of the catalyst inside the cell is mandatory to guide the design of bio-orthogonal catalysts so they can become actual tools in oncology.<\/p>\n

We plan to develop and implement correlative approaches combining different imaging techniques including fluorescence, X-ray and electron imaging. Using this new pipelines we will depict the intracellular journey \u2013in a time line\u2013 of selected metallodrugs and reveal where they exert their chemistry. Complementary placements at industrial collaborators interested in developing imaging techniques are anticipated. A comprehensive picture of where and where the metal-based catalyst interferes with the cancer cell machinery will enable the development of artificial catalyst to become new tools against cancer.<\/p>\n

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POSITION DESCRIPTION<\/strong><\/h2>\n

The candidate will have strong synthetic skills, in particular in the synthesis of fluorophores. Although experience with cell cultures is not required an understanding of the human cell and a good grasp of molecular biology will be valued (in particular knowledge on mitochondrial structure and function). Expertise in optical, X-ray, and electron microscopy is not a requirement but a strong interest in imaging techniques and in 3D correlative data analysis is necessary to success in this project.<\/p>\n

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PARTNER ORGANIZATIONS<\/strong><\/h2>\n

The topic builds on an existing collaboration with the ALBA Synchrotron, MISTRAL beamline (Angew. Chem. Int. Ed. 2020, 59, 1270-1278). Depending on the evolution of the project, additional secondments may be considered such as DIAMOND Light Source in Oxford or ESRF in Grenoble.<\/p>\n