{"id":1502,"date":"2023-03-17T13:49:01","date_gmt":"2023-03-17T11:49:01","guid":{"rendered":"https:\/\/idealcofund-project.eu\/postdoc\/?page_id=1502"},"modified":"2023-03-23T12:15:20","modified_gmt":"2023-03-23T10:15:20","slug":"advanced-therapeutics-based-on-nucleic-acids-and-nanoparticles","status":"publish","type":"page","link":"https:\/\/idealcofund-project.eu\/postdoc\/research-topics\/advanced-therapeutics-based-on-nucleic-acids-and-nanoparticles\/","title":{"rendered":"Advanced therapeutics based on nucleic acids and nanoparticles."},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.9.4″ _module_preset=”default” background_enable_image=”off” custom_padding=”2px||12px|||” global_module=”509″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” custom_padding=”4px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider divider_weight=”60px” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][lwp_divi_breadcrumbs home_text=”Inicio” use_before_icon=”off” link_color=”#89B7CA” current_text_color=”#001733″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” custom_margin=”||29px|||” global_colors_info=”{}”]<\/p>\n

RESEARCH PROGRAMMES <\/strong><\/h2>\n

P3: Nanomedicine against cancer and infection<\/p>\n

P4: Nanomagnetism and critical raw materials<\/p>\n

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RESEARCH SUPERVISOR(S)<\/strong><\/h2>\n

Prof. \u00c1lvaro Somoza
Research Group website: https:\/\/nanociencia.imdea.org\/nanobiotechnology\/group-home<\/a> \/\/\u00a0 www.nanobioimdea.com<\/a><\/span><\/p>\n

Dr Gorka Salas
Research Group website: https:\/\/www.nanociencia.imdea.org\/magnetic-nanoparticles\/group-home<\/a><\/p>\n

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RESEARCH TOPIC DESCRIPTION<\/strong><\/h2>\n

The candidate will develop new therapeutic systems based on nucleic acids and nanoparticles. Particularly, the nucleic acids will be mainly based on modified siRNAs and antisense oligonucleotides to regulate non-coding RNAs (e.g., microRNAs, LncRNAs). The chemical modifications will be synthesized in the lab and incorporated into the oligonucleotides using an automated DNA\/RNA synthesizer. These derivatives will be tested in cell culture for the treatment of different diseases, such as pancreatic cancer, uveal melanoma, and Duchenne muscular dystrophy. Different parameters will be evaluated, such as activity, stability, and selectivity. Then, the selected therapeutic nucleic acids will be further modified to ease their conjugation to nanoparticles, such as gold, iron oxide, or albumin, and control the release inside target cells. The linkers developed will also be employed in the implementation of the synthesis into a flow process during her\/his secondment at the company Synthelia. Additionally, to improve the selectivity of the delivery, aptamers will be included in the formulation.<\/p>\n

Furthermore, the inherent properties of the nanoparticles will also be studied and exploited for enhanced effect. For instance, the targeting properties of albumin will be considered, as well as the synergistic effect of hyperthermia-based approaches using metallic nanoparticles. Also, the imaging capabilities of the nanoparticles will be assessed in combination with the therapy for the development of theranostic systems.<\/p>\n

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POSITION DESCRIPTION<\/strong><\/h2>\n

The candidate should have experience in organic chemistry, which skills will be used for the preparation of linkers and nucleic acids. Experience in the preparation of inorganic nanomaterials functionalized with bioactive molecules, as well as in studying their interaction with cells, is strongly recommended.<\/p>\n

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PARTNER ORGANIZATIONS<\/strong><\/h2>\n

The secondment will be carried out at Synthelia, where the candidate will develop a Flow process for the preparation of new modified nanoparticles.<\/p>\n

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<\/span> Inicio<\/span><\/a><\/span> &#x39;<\/span> <\/span><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>RESEARCH PROGRAMMES P3: Nanomedicine against cancer and infection P4: Nanomagnetism and critical raw materialsRESEARCH SUPERVISOR(S) Prof. \u00c1lvaro SomozaResearch Group website: https:\/\/nanociencia.imdea.org\/nanobiotechnology\/group-home \/\/\u00a0 www.nanobioimdea.com Dr Gorka SalasResearch Group website: https:\/\/www.nanociencia.imdea.org\/magnetic-nanoparticles\/group-homeRESEARCH TOPIC DESCRIPTION The candidate will develop new therapeutic systems based on nucleic acids and nanoparticles. Particularly, the nucleic […]<\/p>\n","protected":false},"author":156,"featured_media":0,"parent":625,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1502","page","type-page","status-publish","hentry"],"yoast_head":"\nAdvanced therapeutics based on nucleic acids and nanoparticles. - IDEAL Postdoctoral Cofund<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advanced therapeutics based on nucleic acids and nanoparticles. - IDEAL Postdoctoral Cofund\" \/>\n<meta property=\"og:description\" content=\"RESEARCH PROGRAMMES P3: Nanomedicine against cancer and infection P4: Nanomagnetism and critical raw materialsRESEARCH SUPERVISOR(S) Prof. \u00c1lvaro SomozaResearch Group website: https:\/\/nanociencia.imdea.org\/nanobiotechnology\/group-home \/\/\u00a0 www.nanobioimdea.com Dr Gorka SalasResearch Group website: https:\/\/www.nanociencia.imdea.org\/magnetic-nanoparticles\/group-homeRESEARCH TOPIC DESCRIPTION The candidate will develop new therapeutic systems based on nucleic acids and nanoparticles. 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