{"id":1436,"date":"2023-03-14T18:18:28","date_gmt":"2023-03-14T16:18:28","guid":{"rendered":"https:\/\/idealcofund-project.eu\/postdoc\/?page_id=1436"},"modified":"2023-03-14T18:20:49","modified_gmt":"2023-03-14T16:20:49","slug":"super-resolution-imaging-of-cell-response-to-nanomechanical-actuation","status":"publish","type":"page","link":"https:\/\/idealcofund-project.eu\/postdoc\/research-topics\/super-resolution-imaging-of-cell-response-to-nanomechanical-actuation\/","title":{"rendered":"Super-resolution imaging of cell response to nanomechanical actuation"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.9.4″ _module_preset=”default” background_enable_image=”off” custom_padding=”2px||12px|||” global_module=”509″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” custom_padding=”4px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider divider_weight=”60px” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][lwp_divi_breadcrumbs home_text=”Inicio” use_before_icon=”off” link_color=”#89B7CA” current_text_color=”#001733″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][\/lwp_divi_breadcrumbs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”||29px|||” global_colors_info=”{}”]

RESEARCH PROGRAMMES <\/strong><\/h2>\n

P4: Nanomedicine against cancer and infection<\/p>[\/et_pb_text][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”]

RESEARCH SUPERVISOR(S)<\/strong><\/h2>\n

Dr Cristina Flors
<\/span><\/p>\n

Research Group website: https:\/\/nanociencia.imdea.org\/home-en\/people\/item\/cristina-flors-ong<\/a><\/span><\/span><\/p>\n

Dr Isabel Rodr\u00edguez
<\/span><\/p>\n

Research Group website: https:\/\/nanociencia.imdea.org\/nanostructured-functional-surfaces-program\/group-home<\/a><\/span><\/p>[\/et_pb_text][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” custom_margin=”27px||29px|||” custom_padding=”||0px|||” global_colors_info=”{}”]

RESEARCH TOPIC DESCRIPTION<\/strong><\/h2>\n

Super-resolution fluorescence microscopy (SRFM) is able to improve by an order of magnitude the spatial resolution in light microscopy, and is already having a massive impact in understanding biology at the nanoscale in living systems. Our laboratory is interested in the development of SRFM methods, from new fluorescence labelling strategies to novel hardware implementations. This project aims to apply SRFM to understand the nanoscale interaction between eukaryotic cells and nanomaterials, with particular emphasis on mechanical effects. Specifically, we are interested in nanopillared surfaces as mechanical actuators that can change the nanoscale distribution of chromatin and its downstream effects. Understanding nuclear mechanics and mechanotransduction at the nanoscale is highly relevant to a number of diseases such as muscular dystrophy, progeria or cancer.<\/p>[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.19.0″ _module_preset=”default” custom_margin=”||29px|||” global_colors_info=”{}”]

POSITION DESCRIPTION<\/strong><\/h2>\n

The candidate should have a background in Biochemistry, Molecular and Cellular Biology, Biophysics or similar. Previous experience in human cell culture and super-resolution fluorescence microscopy, including advanced image analysis, is essential, and knowledge of chromatin structure and function would be very valuable.<\/p>[\/et_pb_text][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”]

PARTNER ORGANIZATIONS<\/strong><\/h2>\n

Previous collaborating institutions that are relevant to this project are Centro Nacional de Biotecnolog\u00eda<\/em> and Centro Nacional de Investigaciones Oncol\u00f3gicas<\/em>. Depending on the evolution of the project and the interests of the candidate, other secondments may be considered.<\/p>\n